Walter de Maria: "Every work of art should have at least ten different meanings".
Lori McNee: "Utilize historical works. or nostalgia for things lost. to help you create artwork that is meaningful" to others.
Here's another link if the first one doesn't work for you.
The key to making meaningful work is to make it about something that really inspires you, something you know intimately - whose sights, sounds and smells come back to you constantly, whose colors and textures fascinate you. Many painters have made work like this: think about Marc Chagall's paintings which always reference the village he left long ago. John Marin's sea paintings, and Wyeth's series about Helga.